Wolfgang Löscher Selected Research

Member 1 Subfamily B ATP Binding Cassette Transporter

1/2022	Epilepsy and Alterations of the Blood-Brain Barrier: Cause or Consequence of Epileptic Seizures or Both?
10/2020	Novel Intrinsic Mechanisms of Active Drug Extrusion at the Blood-Brain Barrier: Potential Targets for Enhancing Drug Delivery to the Brain?
9/2018	Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches.
10/2016	Knockout of P-glycoprotein does not alter antiepileptic drug efficacy in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
6/2015	The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2).
1/2015	Sucrose consumption test reveals pharmacoresistant depression-associated behavior in two mouse models of temporal lobe epilepsy.
6/2014	Marked differences in the effect of antiepileptic and cytostatic drugs on the functionality of P-glycoprotein in human and rat brain capillary endothelial cell lines.
10/2013	(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.
4/2013	Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study.
1/2012	A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.

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Wolfgang Löscher Research Topics

Disease

140	Epilepsy (Aura) 01/2022 - 01/2002
109	Seizures (Absence Seizure) 01/2022 - 01/2002
46	Temporal Lobe Epilepsy 01/2021 - 01/2002
45	Status Epilepticus (Complex Partial Status Epilepticus) 10/2021 - 01/2002
22	Drug Resistant Epilepsy 01/2022 - 04/2002
16	Brain Diseases (Brain Disorder) 01/2022 - 01/2002
15	Neoplasms (Cancer) 06/2021 - 03/2002
14	Breast Neoplasms (Breast Cancer) 06/2015 - 03/2002
11	Partial Epilepsies (Epilepsy, Partial) 01/2021 - 07/2002
5	Brain Injuries (Brain Injury) 10/2021 - 07/2010
5	Infections 01/2021 - 08/2005
5	Nervous System Diseases (Neurological Disorders) 12/2020 - 04/2014
4	Asphyxia (Suffocation) 01/2022 - 01/2021
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 12/2015
4	Stroke (Strokes) 01/2021 - 07/2004
4	Tuberous Sclerosis (Bourneville's Disease) 12/2020 - 01/2018
3	Drug-Related Side Effects and Adverse Reactions 01/2022 - 01/2009
3	Neuralgia (Stump Neuralgia) 01/2021 - 07/2004
3	Migraine Disorders (Migraine) 01/2021 - 07/2004
3	Viral Encephalitis 11/2018 - 01/2018
3	Pain (Aches) 06/2017 - 07/2004
3	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2015 - 12/2010
3	Craniocerebral Trauma (Head Injury) 04/2013 - 07/2004
2	Polyneuropathies (Polyneuropathy) 01/2022 - 06/2017
2	Glycogen Storage Disease Type II (Pompe's Disease) 12/2021 - 04/2021
2	Cognitive Dysfunction 10/2021 - 11/2016
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2021 - 01/2007
2	Critical Illness (Critically Ill) 01/2021 - 12/2016
2	Wounds and Injuries (Trauma) 01/2020 - 01/2019
2	Central Nervous System Diseases (CNS Diseases) 11/2018 - 01/2005
2	Carcinoma (Carcinomatosis) 11/2018 - 01/2012

Drug/Important Bio-Agent (IBA)

77	Pharmaceutical PreparationsIBA 01/2022 - 01/2002
75	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 01/2002
30	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2022 - 04/2002
30	Kainic Acid (Kainate)IBA 01/2021 - 01/2002
27	Pilocarpine (Ocusert)FDA LinkGeneric 10/2021 - 04/2002
24	Phenobarbital (Luminal)FDA Link 01/2021 - 07/2002
18	Bumetanide (Bumex)FDA LinkGeneric 01/2022 - 06/2010
16	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2004
13	Phenytoin (Dilantin)FDA LinkGeneric 07/2017 - 09/2002
12	Levetiracetam (Keppra)FDA LinkGeneric 01/2021 - 04/2002
9	Biomarkers (Surrogate Marker)IBA 01/2020 - 03/2015
8	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2022 - 06/2013
8	GABA-A Receptors (GABA(A) Receptor)IBA 05/2016 - 07/2004
7	Valproic Acid (Depakote)FDA LinkGeneric 07/2017 - 01/2002
7	Pentylenetetrazole (Metrazol)IBA 07/2017 - 10/2008
7	Diazepam (Valium)FDA LinkGeneric 10/2016 - 10/2002
6	LithiumIBA 10/2021 - 10/2009
6	gamma-Aminobutyric Acid (GABA)IBA 01/2021 - 07/2002
6	ChloridesIBA 01/2021 - 06/2010
6	Sodium-Potassium-Chloride SymportersIBA 12/2018 - 02/2014
5	Drug CombinationsIBA 01/2022 - 12/2015
5	Protein Isoforms (Isoforms)IBA 12/2018 - 06/2013
5	AWD 131-138IBA 01/2017 - 10/2004
5	BenzodiazepinesIBA 05/2016 - 10/2004
5	tariquidar (XR9576)IBA 04/2013 - 12/2009
4	Mechanistic Target of Rapamycin Complex 1IBA 12/2020 - 01/2018
4	Sirolimus (Rapamycin)FDA Link 12/2020 - 11/2018
4	pqr620IBA 12/2020 - 01/2018
4	Neuroprotective AgentsIBA 01/2019 - 01/2002
4	Isoflurane FDA LinkGeneric 01/2018 - 02/2016
4	Lamotrigine (Lamictal)FDA LinkGeneric 07/2017 - 07/2002
4	Carbamazepine (Tegretol)FDA LinkGeneric 10/2016 - 01/2009
3	Member 2 Solute Carrier Family 12IBA 01/2022 - 01/2021
3	ezogabine (retigabine)IBA 01/2022 - 01/2002
3	Anti-Anxiety Agents (Anxiolytics)IBA 01/2022 - 01/2014
3	Aminobutyrates (Aminobutyric Acid)IBA 01/2022 - 01/2021
3	AlbuminsIBA 01/2022 - 01/2018
3	Cholinergic Agents (Cholinergics)IBA 10/2021 - 10/2009
3	DiureticsIBA 01/2021 - 02/2014
3	ProdrugsIBA 01/2021 - 06/2010
3	CytokinesIBA 01/2021 - 01/2017
3	PQR530IBA 12/2020 - 01/2018
3	trans-sodium crocetinate (crocetin)IBA 12/2020 - 11/2018
3	MTOR InhibitorsIBA 12/2020 - 01/2018
3	Topiramate (Topamax)FDA LinkGeneric 01/2020 - 11/2009
3	salicylhydroxamic acid (SHAM)IBA 11/2018 - 09/2009
3	AMPA Receptors (AMPA Receptor)IBA 01/2017 - 10/2011
3	multidrug resistance-associated protein 1IBA 10/2013 - 02/2004
3	ElacridarIBA 04/2013 - 04/2011
3	Glutamic Acid (Glutamate)FDA Link 02/2013 - 01/2002
2	Rituximab (Mabthera)FDA Link 01/2022 - 03/2019
2	Scopolamine (Hyoscine)FDA Link 10/2021 - 08/2015
2	Felbamate (Felbatol)FDA Link 01/2021 - 07/2002
2	BumepamineIBA 01/2021 - 12/2018
2	azosemideIBA 01/2021 - 01/2021
2	Everolimus FDA Link 12/2020 - 01/2018
2	Adenosine Triphosphate (ATP)IBA 12/2020 - 01/2020
2	Phosphotransferases (Kinase)IBA 11/2020 - 09/2015
2	Vigabatrin FDA Link 01/2020 - 05/2012
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2019 - 04/2008
2	K Cl- CotransportersIBA 12/2018 - 06/2013
2	AntibodiesIBA 01/2018 - 04/2005
2	2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)IBA 01/2017 - 08/2015

Therapy/Procedure

54	Therapeutics 01/2022 - 03/2002
14	Drug Therapy (Chemotherapy) 01/2022 - 03/2002
4	Electrodes (Electrode) 01/2021 - 05/2014
2	Home Infusion Therapy 12/2021 - 04/2021
2	Polypharmacy 01/2021 - 03/2015
2	Injections 01/2017 - 01/2002